Penn Medicine Strikes Multi-Year Deal with K Health to Deploy AI Clinical Agents Across Its Health System

The University of Pennsylvania Health System has agreed to a multi-year partnership with K Health to deploy artificial intelligence clinical agents across its electronic health records systems, the companies announced Tuesday, adding the prominent academic medical center to a client roster that already includes several large U.S. health systems.

The collaboration will begin with Penn Medicine On-Demand, the health system's virtual urgent care program, before expanding into in-person primary care and selected specialties, including cardiology and dermatology, across Penn's network of clinics.

The AI platform is designed to automate patient intake and clinical documentation. According to the two organizations, the system interviews patients conversationally and converts their responses into structured medical data, pre-populating draft clinical charts within the provider's EHR before the visit begins.

Mitchell Schnall, M.D., Ph.D., Penn Medicine's senior vice president for data and technology solutions and a professor of radiology, said in a statement that the health system sees AI as a "clinical opportunity for the goal of improving patient care" and that the work "will allow us to continue to test how AI can best be used across the spectrum of care, according to Fierce Healthcare

The stated aims of the collaboration are to reduce wait times, support clinicians so they can focus on higher-acuity decisions, and make it easier for patients to understand and follow their care plans.

As part of the arrangement, K Health will provide a set of patient- and clinician-facing agents designed to work inside Penn Medicine's existing digital systems and EHRs. The company says its platform is trained on real-world medical interactions and structured clinical data.

Ran Shaul, co-founder and chief product officer of K Health, said in a statement that Penn Medicine is making "a major investment in K Health as a part of its clinical AI infrastructure," describing the platform not as a point solution but as a layer that "prepares the visit, and connects every patient question to a safe, navigable path inside the system," according to Fierce Healthcare.

The two organizations said the partnership also includes peer-reviewed research initiatives to measure the impact of clinical AI on workflow efficiency, patient engagement, and care delivery outcomes. K Health said it has previously published research with other academic medical centers on AI-enabled primary care automation and chronic disease management, according to Digital Health News.

The Penn Medicine deal is the latest in a series of agreements K Health has struck with large U.S. health systems. Over the last two years, the company has partnered with five major health systems -- Cedars-Sinai, Mayo Clinic, Hackensack Meridian Health, Hartford HealthCare, and Mass General Brigham -- to launch round-the-clock virtual primary care platforms. In November 2025, Northwell Health, New York's largest not-for-profit health system, announced it would power its Northwell Primary Care Now virtual platform with K Health's AI.

Founded in 2016 and headquartered in New York City, K Health has raised $384 million in total venture financing. Investors include Valor Equity Partners, Claure Group, Mangrove Capital Partners, and Comcast Ventures, among others.

The Penn Medicine announcement did not disclose the financial terms of the agreement.

Posted by MedCloudInsider Editors on 05/31/2026